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Donna L. McPhie, Ph.D.
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Director, Cellular Neuropsychiatry Laboratory
Program for Neuropsychiatric Research, McLean Hospital
Instructor in Psychiatry, Harvard Medical School
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 I am the director of the Cellular Neuropsychiatry Laboratory at McLean Hospital. Our lab has reprogrammed 20 subject lines through Cellular Reprogramming. We have had great success with expanding all of these lines and have found them stable over passaging. We have also used a number of the Cellular Reprogramming lines in an oligodendrocyte differentiation protocol that involves differentiation of over 85 days. In this complex differentiation we find that the Cellular Reprogramming lines behave in a manner similar or better than lines reprogrammed from other sources. Additional pluses are that the cost of the process is very reasonable and that they have excellent customer service. I will definitely be sending more lines to Cellular Reprogramming and I strongly recommended Cellular Reprogramming to colleagues.
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Vikram Khurana, M.D., Ph.D.
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Principal Investigator and Associate Neurologist
Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital
Principal Faculty, Harvard Stem Cell Institute, Harvard Medical School
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I am a Principal Faculty Member at the Harvard Stem Cell Institute, based at Brigham and Women's
Hospital in Boston. Recently, we reprogrammed approximately 20 fibroblast lines to iPSc with Cellular
Reprogramming, Inc. I would highly recommend their services. Luigi Warren was professional, personable
and delivered on his word. Stated timelines for the work orders were met, and the entire process was
efficient and stress-free. Moreover, as has been noted by others, costing was highly competitive and
highly enabling for our projects. Reprogramming was achieved for all lines, with only a couple of lines
requiring a second attempt (at no extra cost to us). So far, all the resultant lines we have thawed have
thawed out easily, exhibited normal karyotype and have readily differentiated into neurons. Clients should
be aware that the iPSc lines from Cellular Reprogramming are polyclonal, and understand the implications
of that. Typically, after genome editing, our lab subclones out lines, and so beginning with a polyclonal
population is immaterial. While polyclonal lines might theoretically be expected to drift with multiple
passages, they also avoid potential reprogramming biases originating from single fibroblasts. In any case,
as noted above, subcloning is straightforward if desired. In sum, Cellular Reprogramming offers a terrific
service to generate iPSc with a standard (mRNA-based) non integrating method. Their highly competitive pricing
is enabling for larger scale projects, and they have been a pleasure to deal with. I would highly recommend
them to anyone in academia or industry.
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Sangmi Chung, Ph.D.
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Associate Professor of Cell Biology and Anatomy
New York Medical College
Instructor-Harvard University
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Our lab has reprogrammed more than twenty lines for the last couple of
years through Cellular Reprogramming, Inc. and had excellent experience
with them. They delivered quality product within a give time line and
backed their product with excellent customer support. For example, they
re-reprogrammed failed lines free of charge and in rare case when their
stock does not revive well, they were willing to provide replacement
stocks. All their lines are very stable over extended passaging and well
maintained their differentiation potential. Their pricing was very
reasonable and all our questions were answered in a timely manner.
Based on our excellent experience we had, I strongly recommend Cellular
Reprogramming, Inc to other investigators for their reprogramming needs.
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